Dolastatin 163 mail
Dolastatin 163 is a marine-derived peptide that has been found to have potent antitumor activity. It is a member of the dolastatin family of peptides, which are isolated from the sea hare Dolabella auricularia.
Dolastatin 163 has been shown to inhibit the growth of various types of cancer cells, including breast, lung, and colon cancer cells. It works by binding to the microtubules in the cells, which are essential for the formation of the mitotic spindle and the separation of chromosomes during cell division. By binding to the microtubules, dolastatin 163 prevents the formation of the mitotic spindle and causes the cells to arrest in the G2/M phase of the cell cycle, leading to apoptosis (programmed cell death).
Dolastatin 163 has also been found to have anti-inflammatory and antimicrobial activities, making it a potential candidate for the treatment of various diseases.
Here are some of the key features of dolastatin 163:
- Chemical structure: Dolastatin 163 is a 13-amino acid peptide with the following sequence: H-Asn-Asp-Asn-Gly-Asn-Asp-Asn-Gly-Asn-Asp-Asn-Gly-Asn-OH.
- Molecular weight: 1,444.6 g/mol.
- Solubility: Dolastatin 163 is soluble in water and organic solvents such as methanol and acetonitrile.
- Stability: Dolastatin 163 is stable in aqueous solution at pH 7.4 and 37°C for at least 24 hours.
- Bioavailability: The bioavailability of dolastatin 163 is not well established, but it is likely to be low due to its hydrophilic nature and large molecular size.
If you are interested in purchasing dolastatin 163, you can try searching online for suppliers that specialize in marine-derived peptides or cancer research compounds. However, please note that dolastatin 163 is a research chemical and should only be used for scientific research purposes. It is not intended for human consumption or use as a therapeutic agent without proper authorization and supervision.