Emailers then again crossword puzzle

A crossword puzzle clue!

"Emailers, then again" is likely referring to a phrase that is often used in email subject lines. The answer is likely "RE:".

Here's how it fits:

• "Emailers" refers to the senders of emails.
• "Then again" is a common phrase used in email subject lines to indicate a follow-up or a continuation of a previous conversation.
• "RE:" is an abbreviation for "Respectfully" or "Regarding", which is often used in email subject lines to indicate a response or a follow-up to a previous email.

So, the answer is "RE:".